The Liverpool and Manchester United sides are set to face each other in their first competitive fixture in more than a decade.
Arsenal and Liverpool are set for their first meeting since 2007, and both clubs are still searching for the result.
Liverpool have won seven league matches in a row and are on course for their highest league finish since the late 1970s.
Manchester United have won five league matches this season and are six points clear at the top of the Premier League.
“We’re all feeling pretty good about the way things are going,” Liverpool manager Jurgen Klopp said after the 1-0 defeat at Everton.
“We played some good football in the first half.
We made a couple of changes, but I think that’s part of the game.”
Klopp also praised Liverpool’s players for their display in the second half.
Aston Villa were without goalkeeper Tim Howard and midfielder Ben Davies as the Premier’s Premier League season continued, while Tottenham were without striker Harry Kane and striker Moussa Sissoko.
The hosts have lost three consecutive league matches after they last scored more than twice in December and are now in seventh place, three points adrift of second-placed Chelsea.
They will be without defender Marcos Rojo, who missed the 1,000th Premier League game after suffering a groin injury in training on Monday.
Kane scored the opener and assisted on a second before his second-half strike.
United also missed winger Memphis Depay for the second game in a week after the midfielder’s knee ligament injury.
Both sides had injuries in attack, with Sunderland winger Darren Fletcher, Liverpool striker Harry Wilson and Spurs midfielder Jermain Defoe missing out on the scoring.
Fletcher will be replaced by former United forward Chris Smalling, while United have been without defender Phil Jones, who is out with a knee injury.